منابع مشابه
Next-generation sequencing at Merck-Boston
Next-generation sequencing (NGS) is quickly replacing other methods for determining expression profiling of RNA as well as single-nucleotide variations within the genomes of both model organisms and human samples. At the Boston facility of Merck Research Laboratories, we concentrate on preparation and sequencing of samples where the research needs cannot be met by commercial venders. These unme...
متن کاملFailing the public health--rofecoxib, Merck, and the FDA.
On May 21, 1999, Merck was granted approval by the Food and Drug Administration (FDA) to market rofecoxib (Vioxx). On September 30, 2004, after more than 80 million patients had taken this medicine and annual sales had topped $2.5 billion, the company withdrew the drug because of an excess risk of myocardial infarctions and strokes. This represents the largest prescription-drug withdrawal in hi...
متن کاملPublic Health: Back to the Future
This book is dedicated to and honors the signal career accomplishments and the large professional and personal impact F. Douglas Scutchfield, MD, MPH has had on medicine and public health. Holsinger describes Scutch as a “doctor’s doctor and a public health practitioner’s practitioner.” In many ways Scutch has become an icon in medicine and public health, a larger than life innovator and tour-d...
متن کاملFrom fish poison to merck picrotoxin.
without loss of opioid analgesia. Clin Pharmacol Ther 2010; 87:204–11 5. Dahan A, Aarts L, smith TW: Incidence, reversal, and prevention of opioid-induced respiratory depression. ANEsThEsIoLogy 2010; 112:226–38 6. Boom M, Niesters M, sarton E, Aarts L, smith TW, Dahan A: Non-analgesic effects of opioids: opioid-induced respiratory depression. Curr Pharm Des 2012; 18:5994– 6004 7. okie s: A floo...
متن کاملPutting the public back into public health.
This paper discusses the question of ‘good governance’ in relation to the current debates about global development and health. It explores the challenge of health governance in the face of interconnected complex developmental transitions. Global health is said to be undergoing its third ‘great transition’, the first two transitions being the clean water and sanitation transition in the nineteen...
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ژورنال
عنوان ژورنال: Nature
سال: 1994
ISSN: 0028-0836,1476-4687
DOI: 10.1038/371365b0